The purpose of this presentation is to describe the utility of the High School and Beyond (HSB) cohort for studying the impact of early life circumstances and experiences-- especially education-- on risk of midlife cognitive impairment. This nationally representative cohort has provided 40+ years of prospective data on a variety of topics. The 6th follow-up of the study, performed in 2021-22 with surviving cohort members featured lengthy interviews; a home health visit that included blood and saliva collection and anthropometric measures; and linkages to administrative records (e.g., mortality records, prescription records). Interviews included immediate and delayed recall tasks; a phonemic fluency task; a semantic fluency task; working memory tasks; self- reported memory complaints; and detailed information about health conditions. HSB is now an extraordinary resource for studying—using a large, diverse national sample— the effects of educational contexts, opportunities, and outcomes on midlife cognitive functioning and biological markers of ADRD risk.
AAIC 2023, Amsterdam, Netherlands