Exposure to crime is increasingly recognized as a risk factor for poor health outcomes and premature mortality, with adolescence serving as a period of heightened risk of exposure. As such, identifying the impact of adolescent exposure to crime on long-term health and mortality is critical. Utilizing a nationally representative cohort of high school seniors and sophomores in 1980 (N = 15,720), we examine the effect of residing in a higher crime area in adolescence on self-reported health, physical limitations, all-cause mortality, and deaths of despair at mid-life, as well as differences by demographic characteristics. Our preliminary findings suggest that adolescent crime exposure matters for health at mid-life, underscoring the importance of preventing exposure to crime.